Ledyard is accessible by Interstates 95 and 395 and State Route 2. There are 2 thoroughfares that run north-south through the town:
  • Route 117 in Ledyard Center
  • Route 12 in Gales Ferry
Both connect with Route 2 to the north and Interstate 95 approximately 2 miles south of the town border. Route 214 runs east-west through the town connecting Routes 12, 117 and 2.

For industrial use, Providence and Worcester RR runs along Thames River on west side of Ledyard. There is a spur onto the property of Dow Chemical at Allyn's Point.

Amtrak regional rail services the Northeast Corridor from Washington DC to New York City to Boston with stops in New London.

Shoreline East
Shoreline East commuter rail has a connection to Metro North in New Haven and continuing service to New York City.

Greyhound and Peter Pan buses have stops in New London and at major casinos. SEAT local bus service is available through Ledyard Center and Gales Ferry to Norwich and New London.

Ferry service is available from New London to Long Island, Block Island and Fishers Island year round.

Groton/New London Airport in Groton serves corporate and general aviation. There are 2 commercial airports  approximately 50 miles away from Ledyard:
  • Bradley (Windsor Locks, north of Hartford)
  • TF Green (Providence, Rhode Island)
Most major national carriers serve both airports and Bradley offers European service.